7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
Identifieur interne : 000773 ( Main/Exploration ); précédent : 000772; suivant : 0007747,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
Auteurs : Ibtissam Talhaoui [France] ; Sophie Couvé [France] ; Alexander A. Ishchenko [France] ; Christophe Kunz ; Primo Sch R ; Murat Saparbaev [France]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2012.
Abstract
Hydroxyl radicals predominantly react with the C8 of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway. Here, we report for the first time that human thymine-DNA glycosylase (hTDG) and
Url:
DOI: 10.1093/nar/gks1149
PubMed: 23209024
PubMed Central: 3553953
Affiliations:
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Cancérologie Gustave Roussy, F-94805 Villejuif Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName><orgName type="university">Université Paris-Sud</orgName></affiliation></author><author><name sortKey="Couve, Sophie" sort="Couve, Sophie" uniqKey="Couve S" first="Sophie" last="Couvé">Sophie Couvé</name><affiliation wicri:level="4"><nlm:aff id="gks1149-AFF1">Groupe «Réparation de l’ADN», Université Paris Sud, Laboratoire «Stabilité Génétique et Oncogenèse» CNRS, UMR 8200, Institut de Cancérologie Gustave Roussy, F-94805 Villejuif Cedex,</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea>Groupe «Réparation de l’ADN», Université Paris Sud, Laboratoire «Stabilité Génétique et Oncogenèse» CNRS, UMR 8200, Institut de Cancérologie Gustave Roussy, F-94805 Villejuif Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName><orgName type="university">Université Paris-Sud</orgName></affiliation><affiliation wicri:level="3"><nlm:aff wicri:cut=" and" id="gks1149-AFF1">Génétique Oncologique EPHE, INSERM U753, Institut de cancérologie Gustave Roussy, Villejuif F-94805, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Génétique Oncologique EPHE, INSERM U753, Institut de cancérologie Gustave Roussy, Villejuif F-94805</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ishchenko, Alexander A" sort="Ishchenko, Alexander A" uniqKey="Ishchenko A" first="Alexander A." last="Ishchenko">Alexander A. Ishchenko</name><affiliation wicri:level="4"><nlm:aff id="gks1149-AFF1">Groupe «Réparation de l’ADN», Université Paris Sud, Laboratoire «Stabilité Génétique et Oncogenèse» CNRS, UMR 8200, Institut de Cancérologie Gustave Roussy, F-94805 Villejuif Cedex,</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea>Groupe «Réparation de l’ADN», Université Paris Sud, Laboratoire «Stabilité Génétique et Oncogenèse» CNRS, UMR 8200, Institut de Cancérologie Gustave Roussy, F-94805 Villejuif Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName><orgName type="university">Université Paris-Sud</orgName></affiliation></author><author><name sortKey="Kunz, Christophe" sort="Kunz, Christophe" uniqKey="Kunz C" first="Christophe" last="Kunz">Christophe Kunz</name><affiliation><nlm:aff id="gks1149-AFF1">Department of Biomedicine, University of Basel, Basel, CH-4058 Switzerland</nlm:aff><wicri:noCountry code="subfield">CH-4058 Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Sch R, Primo" sort="Sch R, Primo" uniqKey="Sch R P" first="Primo" last="Sch R">Primo Sch R</name><affiliation><nlm:aff id="gks1149-AFF1">Department of Biomedicine, University of Basel, Basel, CH-4058 Switzerland</nlm:aff><wicri:noCountry code="subfield">CH-4058 Switzerland</wicri:noCountry></affiliation></author><author><name sortKey="Saparbaev, Murat" sort="Saparbaev, Murat" uniqKey="Saparbaev M" first="Murat" last="Saparbaev">Murat Saparbaev</name><affiliation wicri:level="4"><nlm:aff id="gks1149-AFF1">Groupe «Réparation de l’ADN», Université Paris Sud, Laboratoire «Stabilité Génétique et Oncogenèse» CNRS, UMR 8200, Institut de Cancérologie Gustave Roussy, F-94805 Villejuif Cedex,</nlm:aff><country wicri:rule="zip">France</country><wicri:regionArea>Groupe «Réparation de l’ADN», Université Paris Sud, Laboratoire «Stabilité Génétique et Oncogenèse» CNRS, UMR 8200, Institut de Cancérologie Gustave Roussy, F-94805 Villejuif Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName><orgName type="university">Université Paris-Sud</orgName></affiliation></author></analytic><series><title level="j">Nucleic Acids Research</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hydroxyl radicals predominantly react with the C<sub>8</sub> of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway. Here, we report for the first time that human thymine-DNA glycosylase (hTDG) and <italic>Escherichia coli</italic> mismatch-specific uracil-DNA glycosylase (MUG) can remove 8oxoA from 8oxoA•T, 8oxoA•G and 8oxoA•C pairs. Comparison of the kinetic parameters of the reaction indicates that full-length hTDG excises 8oxoA, 3,<italic>N</italic><sup>4</sup>-ethenocytosine (εC) and T with similar efficiency (<italic>k</italic><sub>max</sub> = 0.35, 0.36 and 0.16 min<sup>−1</sup>, respectively) and is more proficient as compared with its bacterial homologue MUG. The N-terminal domain of the hTDG protein is essential for 8oxoA–DNA glycosylase activity, but not for εC repair. Interestingly, the TDG status had little or no effect on the proliferation rate of mouse embryonic fibroblasts after exposure to γ-irradiation. Nevertheless, using whole cell-free extracts from the DNA glycosylase-deficient murine embryonic fibroblasts and <italic>E. coli</italic>, we demonstrate that the excision of 8oxoA from 8oxoA•T and 8oxoA•G has an absolute requirement for TDG and MUG, respectively. The data establish that MUG and TDG can counteract the genotoxic effects of 8oxoA residues <italic>in vivo</italic>.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cadet, J" uniqKey="Cadet J">J Cadet</name></author><author><name sortKey="Douki, T" uniqKey="Douki T">T Douki</name></author><author><name sortKey="Gasparutto, D" uniqKey="Gasparutto D">D Gasparutto</name></author><author><name sortKey="Ravanat, Jl" uniqKey="Ravanat J">JL Ravanat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dizdaroglu, M" uniqKey="Dizdaroglu M">M Dizdaroglu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonicel, A" uniqKey="Bonicel A">A Bonicel</name></author><author><name sortKey="Mariaggi, N" uniqKey="Mariaggi N">N Mariaggi</name></author><author><name sortKey="Hughes, E" uniqKey="Hughes E">E Hughes</name></author><author><name sortKey="Teoule, R" uniqKey="Teoule R">R 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At" uniqKey="Yeung A">AT Yeung</name></author><author><name sortKey="Matsumoto, Y" uniqKey="Matsumoto Y">Y Matsumoto</name></author><author><name sortKey="Bellacosa, A" uniqKey="Bellacosa A">A Bellacosa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kavli, B" uniqKey="Kavli B">B Kavli</name></author><author><name sortKey="Sundheim, O" uniqKey="Sundheim O">O Sundheim</name></author><author><name sortKey="Akbari, M" uniqKey="Akbari M">M Akbari</name></author><author><name sortKey="Otterlei, M" uniqKey="Otterlei M">M Otterlei</name></author><author><name sortKey="Nilsen, H" uniqKey="Nilsen H">H Nilsen</name></author><author><name sortKey="Skorpen, F" uniqKey="Skorpen F">F Skorpen</name></author><author><name sortKey="Aas, Pa" uniqKey="Aas P">PA Aas</name></author><author><name sortKey="Hagen, L" uniqKey="Hagen L">L Hagen</name></author><author><name sortKey="Krokan, He" uniqKey="Krokan H">HE Krokan</name></author><author><name sortKey="Slupphaug, G" uniqKey="Slupphaug G">G Slupphaug</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vasovcak, P" uniqKey="Vasovcak P">P Vasovcak</name></author><author><name sortKey="Krepelova, A" uniqKey="Krepelova A">A Krepelova</name></author><author><name sortKey="Menigatti, M" uniqKey="Menigatti M">M Menigatti</name></author><author><name sortKey="Puchmajerova, A" uniqKey="Puchmajerova A">A Puchmajerova</name></author><author><name sortKey="Skapa, P" uniqKey="Skapa P">P Skapa</name></author><author><name sortKey="Augustinakova, A" uniqKey="Augustinakova A">A Augustinakova</name></author><author><name sortKey="Amann, G" uniqKey="Amann G">G Amann</name></author><author><name sortKey="Wernstedt, A" uniqKey="Wernstedt A">A Wernstedt</name></author><author><name sortKey="Jiricny, J" uniqKey="Jiricny J">J Jiricny</name></author><author><name sortKey="Marra, G" uniqKey="Marra G">G Marra</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Villejuif</li></settlement><orgName><li>Université Paris-Sud</li></orgName></list><tree><noCountry><name sortKey="Kunz, Christophe" sort="Kunz, Christophe" uniqKey="Kunz C" first="Christophe" last="Kunz">Christophe Kunz</name><name sortKey="Sch R, Primo" sort="Sch R, Primo" uniqKey="Sch R P" first="Primo" last="Sch R">Primo Sch R</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Talhaoui, Ibtissam" sort="Talhaoui, Ibtissam" uniqKey="Talhaoui I" first="Ibtissam" last="Talhaoui">Ibtissam Talhaoui</name></region><name sortKey="Couve, Sophie" sort="Couve, Sophie" uniqKey="Couve S" first="Sophie" last="Couvé">Sophie Couvé</name><name sortKey="Couve, Sophie" sort="Couve, Sophie" uniqKey="Couve S" first="Sophie" last="Couvé">Sophie Couvé</name><name sortKey="Ishchenko, Alexander A" sort="Ishchenko, Alexander A" uniqKey="Ishchenko A" first="Alexander A." last="Ishchenko">Alexander A. Ishchenko</name><name sortKey="Saparbaev, Murat" sort="Saparbaev, Murat" uniqKey="Saparbaev M" first="Murat" last="Saparbaev">Murat Saparbaev</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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